Traditional bone marrow aspiration needles aspirate primarily through an open-ended cannula, which leads to excess peripheral blood dilution and inadequate collection of key stem and progenitor cells.  For this reason a high volume of bone marrow aspirate must be collected and then manipulated (i.e. centrifuged) before being utilized for regenerative therapies.

Jamshidi needles were designed to draw very small volumes from multiple insertion points. This technique was subsequently modified by limiting the insertion points and drawing larger volumes (60-240 mL). The aspirate was then reduced through centrifugation due to peripheral blood dilution. This technique delivers low numbers of fibroblastic-like stem cells and is often augmented with expensive allograft alternatives to complete the biologic profile for tissue regeneration.